Impact of aqueous micellar media on biocatalytic transformations involving transaminase (ATA); applications to chemoenzymatic catalysis
نویسندگان
چکیده
Surfactant-enabled asymmetric ATA-catalyzed reductive aminations in aqueous buffered media are described, representative of the enhanced levels conversion made possible by presence a nonionic surfactant water, thereby enabling 1-pot chemoenzymatic catalysis.
منابع مشابه
Chemoenzymatic Kinetic resolution of (R)-malathion in aqueous media
BACKGROUND Malathion (R,S)-diethyl-2-[(dimethoxyphosphorothioyl)sulfanyl]butanedioate is a chiral organophosphorus compound used widely as pesticide for suppression of harmful insects such as mosquitoes. It is well known that in biological systems (R)-malathion is the active enantiomer, therefore a sustainable approach could be the use of only the biologically active enantiomer. The resolution ...
متن کاملCryoenzymology in aqueous media: Micellar solubilized water clusters.
Amphiphilic compounds dissolved in nonpolar organic solvents form inverted micelles whose aqueous centers can solubilize relatively large amounts of enzymes. The solutions are homogeneous and optically transparent and have low viscosity and freezing points; they provide unique and favorable systems to perform the main cryoenzymologic studies previously carried out in mixed solvents. The prepara...
متن کاملSubtilisin Structure and Catalysis in Non - Aqueous Media
................................................................................................. 3 Acknowledgments ................................................................................. 5 Introduction ............................................................................. 7 I. The Crystal Structure of Subtilisin Carlsberg in Anhydrous Dioxane and Its Comparison with Those in W...
متن کاملInvited Review Chemoenzymatic Transformations in Nucleoside Chemistry
During the last quarter of the century almost no other aspect of organic synthesis has received as much attention as the preparation of enantiomerically pure compounds. The synthesis of optically active materials is an important task and represents a challenge to synthetic organic chemists. Increasing interest in the understanding of biological processes and the general recognition that chirali...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Green Chemistry
سال: 2022
ISSN: ['1463-9262', '1463-9270']
DOI: https://doi.org/10.1039/d2gc02002e